Is this the genuine, authentic product?

Yes. It is identical to what you would pay full price for anywhere else, sourced through our authorized supplier relationships.

How is the price below retail?

We buy direct, with nobody in the middle taking a cut, and we sell it for close to what we paid. You see the price privately because you have unlocked the Vault.

How fast does it ship?

Orders placed before 12pm PT are processed the same day and ship within two business days. Shipping is free over $89, and a flat $9.95 under that.

You have 30 days after it arrives to request a return. Product must be unused, in its original packaging, with proof of purchase, and return shipping is paid by you. Find it cheaper anywhere in Canada and we will match the price.

Sisu Sisu - 5-HTP 100mg, 60 caps

Name: Sisu Sisu - 5-HTP 100mg, 60 caps
Brand: Sisu
SKU: sisu-5-htp-100-mg
Price: 29.98 CAD
Availability: InStock

Sisu 5-HTP - A metabolite of the amino acid tryptophan. Proteins in the food we eat provide us with amino acids. One of those amino acids is tryptophan. Tryptophan is broken down by vitamins, enzymes and other co-factors, into 5-HTP and then 5-HTP is turned into serotonin. Serotonin is the neurotransmitter that tells your brain that you are satisfied and do not need to eat anymore. Serotonin deficiency contributes to weight gain, anxiety, sleeplessness and other symptoms. Low serotonin levels also lead to carbohydrate cravings (sugar cravings) and overeating. 5-HTP can help reduce appetite, while it also can enhance your mood, and increase your energy levels.

Price

Regular Canadian retail price: $29.98 CAD. Price Vault members pay below retail on this product. Member pricing is private and shown after a free opt-in, with no membership fee, no minimum order and no subscription.

In stock. Free shipping across Canada on orders over $89, flat $9.95 under that. 30 days to request a return, with return shipping paid by the customer. Ships from Victoria, BC.

See member pricing on Sisu Sisu - 5-HTP 100mg

Why people keep reordering it

Adaptogen support: Herbs traditionally used to help the body adapt to everyday stress.
Steady energy: Supports balanced energy without the spike and the crash.
Calm focus: Helps you stay even through demanding days.

Best suited to: lies awake for an hour before sleeping, tried tryptophan and found it weak, wants to start low and build slowly.

What the research supports

One capsule is 100 mg of 5-HTP from Griffonia seed. Sixty capsules is twenty days at the label's three a day.

Sleep and mood trials use 100 to 300 mg a day.

Falling asleep (evidence: moderate, from randomized controlled trial): 5-HTP is the step your body takes just before making serotonin, which it converts to melatonin at night. Small trials at 100 to 300 mg report a shorter time to fall asleep.
Mood (evidence: mixed, from randomized controlled trial, systematic review): Serotonin is built from 5-HTP, so supplying it directly skips the slowest step in that chain. Human trials are mostly small and decades old, with real effects in some and none in others.
Appetite (evidence: limited, from randomized controlled trial): Serotonin signalling plays a role in feeling full after eating. The findings behind that rest on a few small trials at 600 to 900 mg a day, double what three capsules give here.

Read the literature: Falling asleep on PubMed, Mood on PubMed, Appetite on PubMed.

Is it right for you

Worth it if

lies awake for an hour before sleeping: 100 mg taken 30 to 60 minutes before bed is the amount most often used for shortening time to fall asleep.
tried tryptophan and found it weak: 5-HTP is one step further along the pathway and is not blocked by the amino acids from your last meal, so it converts more reliably.
wants to start low and build slowly: At one capsule a night this bottle runs two months, which is long enough to know whether 100 mg is doing anything before you go to 300 mg.

Look elsewhere if

anyone on daily medication of any kind: clear a serotonin precursor with a practitioner first. For evening calm with fewer interaction questions, magnesium bisglycinate or L-theanine.
someone who needs a vegetarian capsule: the shell here is gelatin, so look for 5-HTP in a hypromellose capsule.
someone who falls asleep fine but wakes at 3 am: 5-HTP is studied mostly for sleep onset. Magnesium bisglycinate or glycine suit night waking better.

What to expect

For sleep, people who respond usually notice easier drop-off within the first three or four nights. Daytime mood changes, if they come at all, take two to four weeks at 200 to 300 mg a day. Mild nausea in the first week is the common complaint and usually settles once you take it with food.

How it compares

Compared with L-tryptophan: 5-HTP converts more efficiently because it is past the rate-limiting enzyme, and it crosses into the brain without competing with the amino acids from a protein meal. The tradeoff: Tryptophan is gentler on the stomach and has a much wider comfortable dose range. 5-HTP causes nausea in some people, particularly above 100 mg at once.
Compared with melatonin: This works upstream on the serotonin side, which is where your own melatonin is made from, and it also has daytime mood research behind it, which melatonin does not. The tradeoff: Melatonin is cheaper, works the first night, and carries far fewer interaction questions.

Product details

Active ingredient: Sisu - 5-HTP 100mg
Ingredient form: caps
Strength: 100 mg
Servings per container: 60
Suggested use: Take 1 capsule 3 times daily or as directed by a health care practitioner.
Country of manufacture: Canada
Independent testing: independent third-party labs
Certifications: Non-GMO, Made in Canada
Storage: Store in a cool, dry place
Brand: Sisu

How to take it

Take 1 capsule 3 times daily or as directed by a health care practitioner.

Store in a cool, dry place away from direct light.
Keep out of reach of children.
Consult a practitioner if you are pregnant, nursing or on medication.

Ingredients

Each capsule contains

L-5-hydroxytryptophan (5-HTP) from Griffonia simplicifolia seed: 100 mg

Non-medicinal ingredients

Magnesium stearate (vegetable), dicalcium phosphate, croscarmellose sodium, silicon dioxide. Capsule Shell: Gelatin.

Free from

Contains no dairy, wheat, gluten, or soy.

Interactions and cautions

Medications: May interact with thyroid, sedative or immune medication. Review with your practitioner.
Timing: Separate from medications by 2 to 4 hours unless directed otherwise by a healthcare practitioner.
Pregnancy and breastfeeding: Consult a healthcare practitioner before use if pregnant or breastfeeding.
General: Use only as directed. Discontinue and consult a practitioner if you experience an adverse reaction.

This product is not intended to diagnose, treat, cure or prevent disease. Consult a healthcare practitioner before use. Free certified advisors are available at 1-888-386-1211, Mon to Fri, 9am to 5pm PT.

Questions about Sisu - 5-HTP 100mg

Is this the genuine, authentic product?: Yes. It is identical to what you would pay full price for anywhere else, sourced through our authorized supplier relationships.
How is the price below retail?: We buy direct, with nobody in the middle taking a cut, and we sell it for close to what we paid. You see the price privately because you have unlocked the Vault.
How fast does it ship?: Orders placed before 12pm PT are processed the same day and ship within two business days. Shipping is free over $89, and a flat $9.95 under that.
Can I return it?: You have 30 days after it arrives to request a return. Product must be unused, in its original packaging, with proof of purchase, and return shipping is paid by you. Find it cheaper anywhere in Canada and we will match the price.