Preferred Nutrition Preferred Nutrition - Berberine 500mg, 120 vcap
Preferred Nutrition Berberine - 500 mg - A naturally occurring compound from a variety of plants such as barberry, goldenseal and Oregon grape that helps to maintain healthy glucose metabolism and cardiovascular health. Clinical studies have shown that 500 mg of Berberine supports weight management by lowering blood sugar and minimizing the production of insulin, the fat-storing hormone.

Price
Regular Canadian retail price: $36.98 CAD. Price Vault members pay below retail on this product. Member pricing is private and shown after a free opt-in, with no membership fee, no minimum order and no subscription.
In stock. Free shipping across Canada on orders over $89, flat $9.95 under that. 30 days to request a return, with return shipping paid by the customer. Ships from Victoria, BC.
See member pricing on Preferred Nutrition Preferred Nutrition - Berberine 500mg
Why people keep reordering it
Best suited to: someone who eats two solid meals a day, people focused on normal glucose metabolism, anyone who wants berberine alone, not a blend.
What the research supports
Each capsule is 500 mg of berberine hydrochloride, taken twice daily with meals for 1,000 mg a day. The 120 capsule bottle lasts 60 days at that dose.
Trials use 1,000 to 1,500 mg a day, split 2 to 3 times.
- Glucose metabolism (evidence: moderate, from randomized controlled trial, meta-analysis)
- Berberine activates AMPK, the enzyme cells use to pull glucose from the blood when energy runs low, and trials at 1,000 to 1,500 mg a day lower fasting glucose.
- Blood lipids (evidence: moderate, from randomized controlled trial, meta-analysis)
- Pooled trials of berberine at around 1 gram a day show modest reductions in total cholesterol and triglycerides, both markers tied to cardiovascular strain.
- Body weight (evidence: limited, from randomized controlled trial)
- Weight change with berberine is small and inconsistent, typically a kilogram or two over twelve weeks, and usually alongside diet changes that account for part of it.
- Gut bacteria (evidence: limited, from randomized controlled trial)
- Very little berberine is absorbed, so most of it stays in the gut and shifts which bacteria live there, though what that shift means for a person is unclear.
Read the literature: Glucose metabolism on PubMed, Blood lipids on PubMed, Body weight on PubMed, Gut bacteria on PubMed.
Is it right for you
Worth it if
- someone who eats two solid meals a day
- the dose is designed to split 500 mg with each meal, so a two meal pattern fits it without extra reminders.
- people focused on normal glucose metabolism
- AMPK activation is the berberine mechanism with the most human data behind it, at roughly this daily amount.
- anyone who wants berberine alone, not a blend
- 500 mg of berberine HCl per capsule with no chromium, cinnamon or bitter melon padding the label out.
Look elsewhere if
- someone buying it mainly to lose weight
- weight changes in berberine trials are small, a kilogram or two across twelve weeks. Money spent on protein intake and a soluble fibre supplement moves appetite further.
- anyone taking something daily
- check with a practitioner before starting rather than after. Berberine slows the liver enzymes that clear a long list of common compounds, which can push their blood levels up.
- people with an easily upset stomach
- cramping, loose stools and constipation are the usual complaints at 1000 mg. Start with one capsule at the largest meal, or look at a dihydroberberine product, which reaches similar blood levels from a smaller amount of powder in the gut.
What to expect
Digestive grumbling in the first week is the thing people actually notice, and it usually settles. Everything else is invisible without testing: the changes measured in trials showed up on bloodwork at eight to twelve weeks, not in how anyone felt.
How it compares
- Compared with a blended blood sugar formula with chromium and cinnamon
- you get the full 500 mg of berberine per capsule that the trials used, rather than 100 mg of it buried behind a proprietary blend. The tradeoff: no chromium, no cinnamon, and two capsules timed to meals is a stricter routine than one blend capsule with breakfast.
- Compared with berberine phytosome or dihydroberberine
- plain berberine HCl is the form nearly all the human research used, so 500 mg here maps directly onto published doses instead of requiring a conversion. The tradeoff: berberine HCl absorbs poorly, under 1 percent, which is exactly why the dose has to be this large and split across meals. Enhanced forms get there on less powder and are gentler on the gut.
Product details
- Active ingredient
- Berberine (hydrochloride) (Berberis vulgaris) (root bark)
- Ingredient form
- vcap
- Strength
- 500 mg
- Servings per container
- 120
- Suggested use
- Take 1 capsule 2 times daily with meals or as directed by a health care practitioner.
- Country of manufacture
- Canada
- Independent testing
- ISURA
- Certifications
- Non-GMO, Made in Canada
- Storage
- Store in a cool, dry place
- Brand
- Preferred Nutrition
How to take it
Take 1 capsule 2 times daily with meals or as directed by a health care practitioner.
- Store in a cool, dry place away from direct light.
- Keep out of reach of children.
- Consult a practitioner if you are pregnant, nursing or on medication.
Ingredients
Each vegetarian capsule contains
- Berberine (hydrochloride) (Berberis vulgaris) (root bark)
- 500 mg
Non-medicinal ingredients
Vegetarian capsule (carbohydrate gum, purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, stearic acids.
Free from
Contains no artificial preservatives, colours or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.
Interactions and cautions
- Medications
- May interact with certain prescription medications. Review with your pharmacist if you take daily medication.
- Timing
- Separate from medications by 2 to 4 hours unless directed otherwise by a healthcare practitioner.
- Pregnancy and breastfeeding
- Consult a healthcare practitioner before use if pregnant or breastfeeding.
- General
- Use only as directed. Discontinue and consult a practitioner if you experience an adverse reaction.
This product is not intended to diagnose, treat, cure or prevent disease. Consult a healthcare practitioner before use. Free certified advisors are available at 1-888-386-1211, Mon to Fri, 9am to 5pm PT.
Questions about Preferred Nutrition - Berberine 500mg
- Is this the genuine, authentic product?
- Yes. It is identical to what you would pay full price for anywhere else, sourced through our authorized supplier relationships.
- How is the price below retail?
- We buy direct, with nobody in the middle taking a cut, and we sell it for close to what we paid. You see the price privately because you have unlocked the Vault.
- How fast does it ship?
- Orders placed before 12pm PT are processed the same day and ship within two business days. Shipping is free over $89, and a flat $9.95 under that.
- Can I return it?
- You have 30 days after it arrives to request a return. Product must be unused, in its original packaging, with proof of purchase, and return shipping is paid by you. Find it cheaper anywhere in Canada and we will match the price.