Natural Factors Natural Factors - Keto Paleo MacroGest, 60 cap
Natural Factors Keto Paleo MacroGest - Full Spectrum Enzyme Formula - Ideal for anyone eating a ketogenic or paleo diet, this intensive strength digestion formula provides key enzymes to help break down proteins and fats, as well as starches, for better nutrient absorption. Helps decrease bloating after high-caloric, high-fat meals. By enhancing the digestion of animal proteins, Keto Paleo MacroGest supports a normal inflammatory response and may help keep pathogenic microorganisms in check, which can reduce food sensitivities.

Price
Regular Canadian retail price: $24.98 CAD. Price Vault members pay below retail on this product. Member pricing is private and shown after a free opt-in, with no membership fee, no minimum order and no subscription.
In stock. Free shipping across Canada on orders over $89, flat $9.95 under that. 30 days to request a return, with return shipping paid by the customer. Ships from Victoria, BC.
See member pricing on Natural Factors Natural Factors - Keto Paleo MacroGest
Why people keep reordering it
- Researched strains
- Specific, studied strains at counts high enough to reach your gut.
- Guaranteed live cultures
- Potency held through the end of shelf life, not just at manufacture.
- Digestive balance
- Supports regularity, bloating and a healthy gut barrier.
Best suited to: feels heavy and bloated after large protein-heavy meals, eating far more animal protein than they used to, wants enzymes that survive the stomach.
What the research supports
A delayed-release capsule of pancreatic enzymes: 22,000 USP units each of amylase and protease, 1,760 of lipase. Label dose is 3 capsules daily with food.
Pancreatic enzyme products are compared on USP units rather than milligrams. Three capsules a day with food is the label's amount; there is no research target to hit.
- Bloating after meals (evidence: moderate, from randomized controlled trial, crossover trial)
- Lipase breaks dietary fat into smaller pieces the gut can absorb, easing the fullness that follows a heavy meal. Trials using higher lipase amounts than this capsule's 1,760 units found less post-meal bloating.
- Meal digestion (evidence: moderate, from randomized controlled trial, crossover trial)
- Pancreatic and fungal enzymes measurably break protein and starch into smaller, absorbable pieces in the gut. The benefit is real but smaller for someone who is already digesting normally.
- Inflammatory response (evidence: limited, from small clinical studies, in vitro)
- Bromelain and serratiopeptidase have been studied for effects beyond digestion, but that research uses them away from food so they stay intact, and this product is deliberately taken with meals.
- Antioxidant intake (evidence: limited, from small clinical studies, in vitro)
- Rutin research typically uses 500 mg and up, so the 20 mg of rutin and 13 mg of amla here work as supporting amounts rather than doses that stand on their own.
Read the literature: Bloating after meals on PubMed, Meal digestion on PubMed, Inflammatory response on PubMed, Antioxidant intake on PubMed.
Is it right for you
Worth it if
- Feels heavy and bloated after large protein-heavy meals
- The protease side is where this formula is genuinely strong, at 22,000 USP units plus 25,200 HUT of fungal protease, bromelain and papain per capsule.
- Eating far more animal protein than they used to
- A sudden jump in protein load is what this enzyme profile is actually built for, and it is dosed per meal rather than once daily.
- Wants enzymes that survive the stomach
- Pancreatic enzymes are inactivated by stomach acid, and the delayed-release shell is there to carry them into the small intestine where they work.
Look elsewhere if
- Vegetarian, vegan, or avoiding pork
- The pancreatin is from pig pancreas, so the vegetarian capsule shell is misleading here. A fully fungal and plant enzyme blend built on Aspergillus protease, bromelain and papain does the same job without animal material.
- Chasing fat digestion above all
- 1,760 USP lipase units per capsule is modest. Look for a lipase-forward enzyme product that states a high lipase figure, and take ox bile or a bile support product if fat is genuinely the problem.
- Allergic to latex, pineapple, papaya or kiwi
- Bromelain and papain come from pineapple and papaya and the label flags latex-fruit cross-reactivity. Choose a fungal-only enzyme blend.
What to expect
Enzymes act on the meal you take them with, so if this does anything you will notice it after that meal, not after a month. Judge it over three or four heavy meals. The lack of a felt effect on a light or low-fat meal is not a failure, it just means there was nothing much for the extra enzymes to do.
How it compares
- Compared with a plain plant-based enzyme blend
- The 8X pancreatin adds animal-derived amylase, protease and lipase working at small intestine pH, which plant and fungal enzymes only partly cover. The tradeoff: It stops being vegetarian, it cannot be used by anyone sensitive to pork, and it needs the delayed-release shell to get there intact, so the capsule cannot be opened.
- Compared with betaine HCl with pepsin
- This works downstream in the small intestine on protein, starch and fat together, where an acid support product works upstream in the stomach on protein only. The tradeoff: If the actual issue is low stomach acid, this formula does not address it, and the delayed release deliberately bypasses the compartment where that problem lives.
Product details
- Medicinal ingredients
- Pancreatic enzymes 8X* (Sus scrofa) (pancreas), Alpha-amylase 22,000 USP units, Protease 22,000 USP units, Triacylglycerol lipase 1,760 USP units and 5 more
- Ingredient form
- cap
- Servings per container
- 60
- Suggested use
- 1 capsule 3 times daily with food, 2 hours before or after taking other medications, or as directed by a health care practitioner. Swallow whole, do not crush or chew.
- Country of manufacture
- Canada
- Independent testing
- ISURA
- Certifications
- Non-GMO, Made in Canada
- Storage
- Store in a cool, dry place
- Brand
- Natural Factors
How to take it
1 capsule 3 times daily with food, 2 hours before or after taking other medications, or as directed by a health care practitioner. Swallow whole, do not crush or chew.
- Store in a cool, dry place away from direct light.
- Keep out of reach of children.
- Consult a practitioner if you are pregnant, nursing or on medication.
Ingredients
Each vegetarian capsule contains
- Pancreatic enzymes 8X* (Sus scrofa) (pancreas)
- 110 mg
- Alpha-amylase 22,000 USP units
- Protease 22,000 USP units
- Triacylglycerol lipase 1,760 USP units
- High enzyme activity blend of the following
- 63 mg
- Fungal protease (Aspergillus flavus var. oryzae) (whole) 25,200 FCC HUT (31.5 mg)
- Papain (Carica papaya) (fruit) 302,400 FCC PU (7.2 mg)
- Alpha-amylase (Aspergillus flavus var. oryzae) (whole)1,260 FCC DU (8.4 mg)
- Lipase (triacylglycerol lipase) (Rhizopus oryzae) (whole) 25.2 FCC LU (0.72 mg)
- Bromelain (Ananas comosus) (pineapple stem) 378,000 FCC PU (11.45 mg)
- Serratiopeptidas (Serratia marcescens E-15) (whole)
- 7,560 SU (3.44 mg)
- Rutin (Styphnolobium japonicum) (flower bud)
- 20 mg
- Amla (Phyllanthus emblica) (fruit)
- 13 mg
Non-medicinal ingredients
Delayed release vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant).
Free from
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.
Interactions and cautions
- Medications
- May interact with certain prescription medications. Review with your pharmacist if you take daily medication.
- Timing
- If taking antibiotics, separate doses by 2 to 3 hours.
- Pregnancy and breastfeeding
- Consult a healthcare practitioner before use if pregnant or breastfeeding.
- General
- Use only as directed. Discontinue and consult a practitioner if you experience an adverse reaction.
This product is not intended to diagnose, treat, cure or prevent disease. Consult a healthcare practitioner before use. Free certified advisors are available at 1-888-386-1211, Mon to Fri, 9am to 5pm PT.
Questions about Natural Factors - Keto Paleo MacroGest
- Is this the genuine, authentic product?
- Yes. It is identical to what you would pay full price for anywhere else, sourced through our authorized supplier relationships.
- How is the price below retail?
- We buy direct, with nobody in the middle taking a cut, and we sell it for close to what we paid. You see the price privately because you have unlocked the Vault.
- How fast does it ship?
- Orders placed before 12pm PT are processed the same day and ship within two business days. Shipping is free over $89, and a flat $9.95 under that.
- Can I return it?
- You have 30 days after it arrives to request a return. Product must be unused, in its original packaging, with proof of purchase, and return shipping is paid by you. Find it cheaper anywhere in Canada and we will match the price.