Natural Factors Natural Factors - BioCoenzymated Active B Complex, 60 vcap
Natural Factors BioCoenzymated Active B Complex - A one-a-day balanced formula of eight essential B vitamins in their biologically active forms, which do not require conversion by the liver to be absorbed and utilized. Suitable for vegetarians and ideal for energy support, especially during stressful times. B vitamins are essential for healthy tissue and red blood cell formation; for the conversion of carbohydrates, fats, and proteins into energy; for the synthesis of brain chemicals which support mood, nerves and sleep; for healthy hair, skin, nails, and eyesight; and for maintaining healthy cholesterol, blood sugar, and homocysteine.

Price
Regular Canadian retail price: $25.48 CAD. Price Vault members pay below retail on this product. Member pricing is private and shown after a free opt-in, with no membership fee, no minimum order and no subscription.
In stock. Free shipping across Canada on orders over $89, flat $9.95 under that. 30 days to request a return, with return shipping paid by the customer. Ships from Victoria, BC.
See member pricing on Natural Factors Natural Factors - BioCoenzymated Active B Complex
Why people keep reordering it
- Active methylated forms
- B vitamins in the forms your body can put to use right away.
- Mood and hormone balance
- Supports healthy methylation, mood and hormonal rhythm.
- Energy at the cellular level
- Feeds the pathways behind steady, real energy.
Best suited to: wants folate that skips the conversion step, gets flushing from ordinary niacin, wants one capsule rather than a stack of bs.
What the research supports
A one-a-day capsule using active coenzyme forms of the B vitamins, including 400 mcg of 5-MTHF folate and 500 mcg of methylcobalamin B12. The bottle lasts two months.
There is no research dose for a B complex as a whole. Judge it on the individual amounts, and here the 400 mcg of folate and 500 mcg of B12 are the two worth checking against whatever else you take.
- Blood homocysteine (evidence: strong, from randomized controlled trial, meta-analysis)
- Folate, B12 and B6 work together to convert homocysteine back into useful compounds instead of letting it build up. Trials and meta-analyses consistently show this combination, at roughly these amounts, lowers it.
- Blood folate (evidence: strong, from randomized controlled trial, meta-analysis)
- 5-MTHF is the form your body can use directly, skipping a conversion step some people struggle with. Head-to-head trials show it raises plasma and red cell folate at least as well as folic acid.
- Stress and fatigue (evidence: moderate, from randomized controlled trial)
- B vitamins are cofactors your nervous system needs to make energy and calming neurotransmitters under load. High-dose B-complex trials over 4 to 12 weeks report modest drops in self-rated stress in working adults, with small but real effects.
- Energy (evidence: strong, from randomized controlled trial, meta-analysis)
- Thiamine, riboflavin, niacin and pantothenic acid are required cofactors in the pathways that turn food into usable energy. Running low on any of them can leave you eating enough and still feeling flat.
Read the literature: Blood homocysteine on PubMed, Blood folate on PubMed, Stress and fatigue on PubMed, Energy on PubMed.
Is it right for you
Worth it if
- Wants folate that skips the conversion step
- The 400 mcg here is already (6S)-5-methyltetrahydrofolate, the form that circulates in blood, so it does not depend on the enzyme that reduces folic acid.
- Gets flushing from ordinary niacin
- The 100 mg of niacin here is inositol hexanicotinate, which releases slowly and does not produce the flush.
- Wants one capsule rather than a stack of Bs
- Eight B vitamins plus choline and inositol in a single daily vegetarian capsule, taken with food.
Look elsewhere if
- Taking niacin to move blood lipids
- Inositol hexanicotinate at 100 mg does not do that job. A plain nicotinic acid product at a practitioner-set dose is the form that research used.
- Pregnant or planning a pregnancy
- A full prenatal covers the same 400 mcg of folate and adds the iron, iodine and D3 this does not carry.
- Only actually short on B12
- A standalone methylcobalamin at 1000 mcg gives you twice the B12 for a fraction of the price of a full complex.
What to expect
Bright yellow urine within a few hours of the first capsule, from the riboflavin. That is the only thing you will reliably notice. Trials on B complexes and self-rated stress or fatigue measure differences over 4 to 12 weeks, not days.
How it compares
- Compared with a standard B-50 complex with pyridoxine, folic acid and cyanocobalamin
- Every B here arrives in the form the body actually uses, so nothing depends on how well you convert the precursors. The tradeoff: It costs noticeably more, and for most people with normal conversion the cheap forms end up doing the same work.
Product details
- Medicinal ingredients
- Vitamin B1 (thiamine hydrochloride, benfotiamine), Vitamin B2 (riboflavin 5’-phosphate sodium), Niacin (inositol hexanicotinate), Pantothenic acid (calcium d -pantothenate) and 5 more
- Ingredient form
- vcap
- Servings per container
- 60
- Suggested use
- 1 capsule daily with food or as directed by a health care practitioner.
- Country of manufacture
- Canada
- Independent testing
- ISURA
- Certifications
- Non-GMO, Made in Canada
- Storage
- Store in a cool, dry place
- Brand
- Natural Factors
How to take it
1 capsule daily with food or as directed by a health care practitioner.
- Store in a cool, dry place away from direct light.
- Keep out of reach of children.
- Consult a practitioner if you are pregnant, nursing or on medication.
Ingredients
Each vegetarian capsule contains
- Vitamin B1 (thiamine hydrochloride, benfotiamine)
- 31.7 mg
- Vitamin B2 (riboflavin 5’-phosphate sodium)
- 10 mg
- Niacin (inositol hexanicotinate)
- 100 mg
- Pantothenic acid (calcium d -pantothenate)
- 100 mg
- Vitamin B6 (pyridoxal 5’-phosphate)
- 25 mg
- Vitamin B12 (methylcobalamin)
- 500 mcg
- Folate (from (6S)-5-methyltetrahydrofolic acid (MTHF), glucosamine salt, Quatrefolic®)
- 400 mcg
- Biotin
- 250 mcg
- Choline (choline dihydrogen citrate)
- 50 mg
- Inositol (inositol, inositol hexanicotinate)
- 50 mg
Non-medicinal ingredients
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.
Interactions and cautions
- Medications
- May interact with certain prescription medications. Review with your pharmacist if you take daily medication.
- Timing
- Separate from medications by 2 to 4 hours unless directed otherwise by a healthcare practitioner.
- Pregnancy and breastfeeding
- Consult a healthcare practitioner before use if pregnant or breastfeeding.
- General
- Use only as directed. Discontinue and consult a practitioner if you experience an adverse reaction.
This product is not intended to diagnose, treat, cure or prevent disease. Consult a healthcare practitioner before use. Free certified advisors are available at 1-888-386-1211, Mon to Fri, 9am to 5pm PT.
Questions about Natural Factors - BioCoenzymated Active B Complex
- Is this the genuine, authentic product?
- Yes. It is identical to what you would pay full price for anywhere else, sourced through our authorized supplier relationships.
- How is the price below retail?
- We buy direct, with nobody in the middle taking a cut, and we sell it for close to what we paid. You see the price privately because you have unlocked the Vault.
- How fast does it ship?
- Orders placed before 12pm PT are processed the same day and ship within two business days. Shipping is free over $89, and a flat $9.95 under that.
- Can I return it?
- You have 30 days after it arrives to request a return. Product must be unused, in its original packaging, with proof of purchase, and return shipping is paid by you. Find it cheaper anywhere in Canada and we will match the price.