Natural Factors Natural Factors - 5-HTP 200mg - Time Release, 60 Time-Release Tabs
Natural Factors 5-HTP 200mg Time Release - Natural Factors 5-HTP 200 mg provides a higher dose of this free-form amino acid in timed-release tablets. 5-HTP is a direct precursor to serotonin, which helps promote healthy mood balance and can be used as a sleep aid without creating dependence. The timed-release tablets gradually release 5-HTP to minimize gastrointestinal upset and allow for a steadier increase in serotonin. This formula is non-GMO and suitable for vegetarians and vegans.

Price
Regular Canadian retail price: $19.98 CAD. Price Vault members pay below retail on this product. Member pricing is private and shown after a free opt-in, with no membership fee, no minimum order and no subscription.
In stock. Free shipping across Canada on orders over $89, flat $9.95 under that. 30 days to request a return, with return shipping paid by the customer. Ships from Victoria, BC.
See member pricing on Natural Factors Natural Factors - 5-HTP 200mg - Time Release
Why people keep reordering it
- Adaptogen support
- Herbs traditionally used to help the body adapt to everyday stress.
- Steady energy
- Supports balanced energy without the spike and the crash.
- Calm focus
- Helps you stay even through demanding days.
Best suited to: already at 100 mg and want more, queasy on regular 5-htp capsules, mind still running at bedtime, vegans looking at amino acid sleep support.
What the research supports
Each tablet delivers 200 mg of L-5-HTP in a time-release matrix that dissolves over hours instead of all at once. The bottle holds 60 tablets.
Trials use 50 to 300 mg a day, often starting near 100 mg.
- Falling asleep (evidence: moderate, from randomized controlled trial, small human trials)
- 5-HTP is the direct precursor your body turns into serotonin and then melatonin at night. Trials report falling asleep faster and more deep sleep, though most are old and small.
- Mood (evidence: mixed, from randomized controlled trial, systematic review)
- 5-HTP is the raw material your brain converts into serotonin, the neurotransmitter tied to mood. Trial reviews found real signals but rated most too small or loosely run to be sure.
- Appetite (evidence: limited, from small human trials)
- Serotonin from 5-HTP acts on brain circuits that signal fullness. A handful of small short trials found people eating less when taking it before meals.
Read the literature: Falling asleep on PubMed, Mood on PubMed, Appetite on PubMed.
Is it right for you
Worth it if
- Already at 100 mg and want more
- One tablet is a full 200 mg, so you move up a level without doubling capsules.
- Queasy on regular 5-HTP capsules
- The timed-release matrix spreads the 200 mg out over hours rather than releasing it at once, which is the main lever anyone has for reducing that stomach upset.
- Mind still running at bedtime
- The label puts one tablet 60 to 90 minutes before bed, which gives a timed-release tablet the head start it needs to be working as you settle.
- Vegans looking at amino acid sleep support
- The 5-HTP is pulled from Griffonia seed and the tablet carries no animal ingredients, unlike gelatin capsule versions.
Look elsewhere if
- Anyone trying 5-HTP for the first time
- Start on a 50 or 100 mg capsule you can take once and judge honestly. A timed-release tablet is not meant to be split, so this bottle gives you no way to ease in.
- Someone taking daily medication
- Clear it with a practitioner before adding this. 5-HTP feeds the serotonin pathway, and stacking it on top of something already acting there is not a self-start decision.
- Wants something to work tonight
- The label itself asks for two weeks of use. Melatonin acts the same night you take it, which is the better fit if one bad night is the whole problem.
What to expect
For sleep, some people notice they settle faster inside the first week when taking it 60 to 90 minutes before bed. For mood balance the label asks for at least two weeks, and four to six is more realistic. Mild nausea in the first few days is the usual complaint and it generally fades.
How it compares
- Compared with plain immediate-release 5-HTP capsules
- The timed-release matrix meters the 200 mg out gradually, aimed squarely at the nausea that makes people quit plain 5-HTP in the first week. The tradeoff: You pay more per milligram, and you lose the ability to split a dose, because breaking a timed-release tablet destroys the exact mechanism you paid for.
- Compared with melatonin
- 5-HTP works upstream, supplying raw material the body converts onward, rather than delivering a finished hormone signal. The tradeoff: Melatonin has far more human trial data for falling asleep faster, and it works on night one where this bottle asks for two weeks.
Product details
- Active ingredient
- Natural Factors - 5-HTP 200mg - Time Release
- Ingredient form
- Time-Release Tabs
- Strength
- 200 mg
- Servings per container
- 60
- Suggested use
- All uses: Use for at least 2 weeks to see beneficial effects. To minimize the risk of gastrointestinal side effects, start at a lower dose and slowly increase to the effective dose over a 2-week period. For sleep disturbances: 1 tablet daily with food or as directed by a health care practitioner. Take 60–90 minutes before bedtime. For healthy mood balance: 1 tablet daily with food or as directed by a health care practitioner. For migraine prevention: 1 tablet 3 times daily with food or as directed by a health care practitioner. For fibromyalgia symptoms: 1 tablet 2 times daily with food or as directed by a health care practitioner.
- Independent testing
- ISURA
- Certifications
- Non-GMO
- Storage
- Store in a cool, dry place
- Brand
- Natural Factors
How to take it
All uses: Use for at least 2 weeks to see beneficial effects. To minimize the risk of gastrointestinal side effects, start at a lower dose and slowly increase to the effective dose over a 2-week period. For sleep disturbances: 1 tablet daily with food or as directed by a health care practitioner. Take 60–90 minutes before bedtime. For healthy mood balance: 1 tablet daily with food or as directed by a health care practitioner. For migraine prevention: 1 tablet 3 times daily with food or as directed by a health care practitioner. For fibromyalgia symptoms: 1 tablet 2 times daily with food or as directed by a health care practitioner.
- Store in a cool, dry place away from direct light.
- Keep out of reach of children.
- Consult a practitioner if you are pregnant, nursing or on medication.
Ingredients
Each tablet contains
- L-5-HTP (L-5-hydroxytryptophan) (Griffonia simplicifolia) (seed)
- 200 mg
Non-medicinal ingredients
Dicalcium phosphate dihydrate, cellulose, carbohydrate gum, coating (carbohydrate gum, glycerin), vegetable grade magnesium stearate (lubricant).
Free from
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or genetically modified genes or proteins. Suitable for vegetarians/vegans.
Interactions and cautions
- Medications
- May interact with thyroid, sedative or immune medication. Review with your practitioner.
- Timing
- Separate from medications by 2 to 4 hours unless directed otherwise by a healthcare practitioner.
- Pregnancy and breastfeeding
- Consult a healthcare practitioner before use if pregnant or breastfeeding.
- General
- Use only as directed. Discontinue and consult a practitioner if you experience an adverse reaction.
This product is not intended to diagnose, treat, cure or prevent disease. Consult a healthcare practitioner before use. Free certified advisors are available at 1-888-386-1211, Mon to Fri, 9am to 5pm PT.
Questions about Natural Factors - 5-HTP 200mg - Time Release
- Is this the genuine, authentic product?
- Yes. It is identical to what you would pay full price for anywhere else, sourced through our authorized supplier relationships.
- How is the price below retail?
- We buy direct, with nobody in the middle taking a cut, and we sell it for close to what we paid. You see the price privately because you have unlocked the Vault.
- How fast does it ship?
- Orders placed before 12pm PT are processed the same day and ship within two business days. Shipping is free over $89, and a flat $9.95 under that.
- Can I return it?
- You have 30 days after it arrives to request a return. Product must be unused, in its original packaging, with proof of purchase, and return shipping is paid by you. Find it cheaper anywhere in Canada and we will match the price.