Is this the genuine, authentic product?

Yes. It is identical to what you would pay full price for anywhere else, sourced through our authorized supplier relationships.

How is the price below retail?

We buy direct, with nobody in the middle taking a cut, and we sell it for close to what we paid. You see the price privately because you have unlocked the Vault.

How fast does it ship?

Orders placed before 12pm PT are processed the same day and ship within two business days. Shipping is free over $89, and a flat $9.95 under that.

You have 30 days after it arrives to request a return. Product must be unused, in its original packaging, with proof of purchase, and return shipping is paid by you. Find it cheaper anywhere in Canada and we will match the price.

AOR AOR - SAMe 400 400mg, 60 tab

AOR SAMe 400 - S-Adenosyl-L-Methionine (SAMe) is a natural compound and methyl group donor that supports the methylation cycle, a process which is essential for many aspects of health. Methylation is fundamental for ridding the body of certain toxins, and certain people, such as those with chronic liver disorders, cannot produce adequate levels of SAMe. SAMe’s effectiveness to support a balanced mood is demonstrated by many clinical studies. SAMe is in fact so effective for boosting a low mood that it is legally registered as a prescription drug in several European countries for mood balance. It is thought that SAMe works by helping to boost serotonin, dopamine and melatonin levels in the brain, low levels of which are commonly associated with mood imbalances such as anxiety and depression. SAMe has also been found to support joint health in osteoarthritis patients as effectively as a popular anti-inflammatory drug by reducing inflammation and protecting joint tissue from degradation.

Price

Regular Canadian retail price: $108.88 CAD. Price Vault members pay below retail on this product. Member pricing is private and shown after a free opt-in, with no membership fee, no minimum order and no subscription.

In stock. Free shipping across Canada on orders over $89, flat $9.95 under that. 30 days to request a return, with return shipping paid by the customer. Ships from Victoria, BC.

See member pricing on AOR AOR - SAMe 400

Why people keep reordering it

Adaptogen support: Herbs traditionally used to help the body adapt to everyday stress.
Steady energy: Supports balanced energy without the spike and the crash.
Calm focus: Helps you stay even through demanding days.

Best suited to: wants extra mood support beyond diet and lifestyle, dealing with osteoarthritic joint discomfort, prefers taking a supplement in the morning routine.

What the research supports

One tablet holds 400 mg of SAMe. At two to three tablets a day, the 60-tablet bottle lasts three to four weeks.

Studies use 800 to 1200 mg a day.

Joint comfort (evidence: moderate, from randomized controlled trial, meta-analysis): SAMe feeds into pathways that build cartilage, the connective tissue that cushions joints and wears down over time. Trials show improved joint comfort within several weeks of daily use.
Mood balance (evidence: moderate, from randomized controlled trial, meta-analysis): SAMe is a methyl donor your body uses to build serotonin and dopamine, the brain chemicals tied to mood. Trials at these doses show improvement in low mood scores within two weeks.

Read the literature: Joint comfort on PubMed, Mood balance on PubMed.

Is it right for you

Worth it if

Wants extra mood support beyond diet and lifestyle: SAMe at 800 mg and up has clinical trial support for lifting low mood by supporting serotonin and dopamine synthesis.
Dealing with osteoarthritic joint discomfort: Studies at comparable doses show SAMe reducing joint inflammation and slowing cartilage breakdown about as well as standard anti-inflammatory approaches.
Prefers taking a supplement in the morning routine: The label specifically warns against night dosing since SAMe can be activating, so it fits people who take supplements with breakfast.

Look elsewhere if

Anyone with a diagnosed mood disorder under a doctor's care: Raise it with whoever is managing that care before starting. SAMe has real interactions with the medicines used in that setting, and the label says so directly.
Someone who takes supplements right before bed: Look for a magnesium or calming herbal formula instead, since this one is explicitly not meant for evening use.
Pregnant or breastfeeding: Speak with a healthcare practitioner about mood and joint support options that don't involve a 400 mg methyl donor at this stage.

What to expect

For mood support, plan on at least two weeks of daily use before judging effect. For joint comfort, the label calls for a minimum of four weeks. This isn't a same-day feel, it needs a committed run to show whether it's doing anything.

How it compares

Compared with a B-complex or folate supplement for methylation support: SAMe acts further downstream, directly supplying the methyl-donating molecule itself rather than the cofactors needed to produce it. The tradeoff: SAMe tablets cost noticeably more per month than a basic B-complex and need to be taken on an empty stomach for absorption.
Compared with a standard NSAID for joint discomfort: SAMe has been studied at these doses as an alternative that protects joint tissue rather than just masking inflammation short term. The tradeoff: It takes about four weeks of consistent use to notice joint benefits, whereas an anti-inflammatory works within hours.

Product details

Active ingredient: S-Adenosyl-L-Methioinine (SAMe)
Ingredient form: tab
Strength: 400mg
Servings per container: 60
Suggested use: Take two or three tablets daily on an empty stomach, or as directed by a qualified health care practitioner. Use for a minimum of four weeks to see beneficial effects for osteoarthritic pain and a minimum of two weeks for mood support.
Country of manufacture: Canada
Independent testing: ISO-certified third-party labs
Certifications: Non-GMO, Made in Canada
Storage: Store in a cool, dry place
Brand: AOR

How to take it

Take two or three tablets daily on an empty stomach, or as directed by a qualified health care practitioner. Use for a minimum of four weeks to see beneficial effects for osteoarthritic pain and a minimum of two weeks for mood support.

Store in a cool, dry place away from direct light.
Keep out of reach of children.
Consult a practitioner if you are pregnant, nursing or on medication.

Ingredients

Each tablet contains

S-Adenosyl-L-Methioinine (SAMe): 400mg

Non-medicinal ingredients

Stearic acid, magnesium hydroxide, microcrystalline cellulose, calcium oxide, shellac, arginine, magnesium stearate, silica, talc, sodium alginate and glycerol.

Interactions and cautions

Medications: May interact with thyroid, sedative or immune medication. Review with your practitioner.
Timing: Separate from medications by 2 to 4 hours unless directed otherwise by a healthcare practitioner.
Pregnancy and breastfeeding: Consult a healthcare practitioner before use if pregnant or breastfeeding.
General: Use only as directed. Discontinue and consult a practitioner if you experience an adverse reaction.

This product is not intended to diagnose, treat, cure or prevent disease. Consult a healthcare practitioner before use. Free certified advisors are available at 1-888-386-1211, Mon to Fri, 9am to 5pm PT.

Questions about AOR - SAMe 400

Is this the genuine, authentic product?: Yes. It is identical to what you would pay full price for anywhere else, sourced through our authorized supplier relationships.
How is the price below retail?: We buy direct, with nobody in the middle taking a cut, and we sell it for close to what we paid. You see the price privately because you have unlocked the Vault.
How fast does it ship?: Orders placed before 12pm PT are processed the same day and ship within two business days. Shipping is free over $89, and a flat $9.95 under that.
Can I return it?: You have 30 days after it arrives to request a return. Product must be unused, in its original packaging, with proof of purchase, and return shipping is paid by you. Find it cheaper anywhere in Canada and we will match the price.